Human Abortion Virus

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Virus.gif
Unknown
Name:
Pwnage probability: 20%
Primary symptoms: Confidential
Secondary symptom: Confidential
Epic symptoms: Confidential
Classification
Group: Confidential
Order: Confidential
Family: Secret
Genus: Varicellovirus

Human nodantyvirus 1 (HNV-1) is a virus of the family nodantyviridae that causes abortion, respiratory disease and occasionally neonatal mortality in humans. Initial spread of HNV-1 by a newly introduced human through direct and indirect contact can lead to abortion and perinatal infection in up to 70 percent of a previously unexposed herd. Abortion usually occurs in the last four months of gestation, two to four weeks after infection of the mare. Perinatal (around the time of birth) infection can lead to pneumonia and death. Encephalitis can occur in affected animals, leading to ataxia, paralysis, and death. There is a vaccine available, however it’s efficacy is questionable.

The virus cross-reacts with human nodantyvirus 4 in many serological laboratory tests. Commercial diagnostic tests are available to distinguish the two viruses using monoclontal antibody based reagents. The virus is easily isolated in cell culture and can be readily detected during acute infection using molecular diagnostic methods such as polymerase chain reaction (PCR).

Recent molecular epidemiology studies have identified a single nucleotide polymorphism (SNP) which varies between HNV-1 field isolates and shows a highly statistically significant correlation with paralytic compared with non-paralytic disease outbreaks. The SNP corresponds to a single amino acid change in the DNA polymerase enzyme, which is an essential enzyme for replication of viral DNA. This is a significant finding, suggesting that a point mutation in a single virus gene has a major impact upon likely disease severity during an outbreak.

In 2006, an outbreak of HNV-1 among schools in Florida resulted in the institution of various quarantine measures. The outbreak was determined to have originated with several humans imported from Europe via New York, and then shipped to Florida.

References

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